| Directions for Questions 68-73:
Each Question is based on the passage below. After reading the passage, choose the best answer to each Question from the answer choices given below and darken the corresponding oval in the answer sheet. Base your answer on information that is either stated or implied in the passage.
Passage:
Nearly a century ago, biologists found that if they separated an invertibrate animal embryo into two parts at an early stage of its life, it would survive and develop as two normal embryos. This led them to believe that the cells in the early embryo are undetermined in the sense that each cell has the potential to develop in a variety of different ways. Later biologists found that the situation was not so simple. It matters in which plane the embryo is cut. If it is cut in a plane different from the one used by early investigators, it will not form two whole embryos.
A debate arose over what exactly was happening. Which embryo cells are determined, just when do they become irreversely committed to their fates, and what are the “morphogenetic determinants” that tell a cell what to become?
But the debate could not be resolved because no one was able to ask the crucial questions in a form in which they could be pursued productively. Recent discoveries in molecular biology, however, have opened up prospects for a resolution of the debate. Now investigators think they know at least some of the molecules that act as morphogenic determinants in early development. They have been able to show that, in a sense, cell determination begins even before an egg is fertilized.
Studying sea urchins, biologist Paul Gross found that an unfertilized egg contains substances that function as morphogenetic determinants. They are located in the cytoplasm of the egg cell, i.e., in that part of the cell’s protoplasm that lies outside of the nucleus. In the unfertilized egg the substances are inactive and are not distributed homogeneously. When the egg is fertilized, the substance become active and, presumably, govern the behaviour of the genes they interact with. Since the substances are unevenly distributed in the egg, when the fertilized egg divides, the resulting cells are different from the start and so can qualitatively different in their own gene actively.
The substances that Gross studied are maternal messenger RNA’s -------- products of certain of the maternal genes. He and other biologists studying a wide variety of organisms have found that these particular RNA’s direct, large part, the synthesis of histones, a class of proteins that bind to DNA. Once synthesized, the histones move into the cell nucleus, where sections of DNA wrap around them to form a structure that resembles beads or knots, on a string. The beads are DNA segments wrapped around histones; the string is the intervening DNA. And it is the structure of these beaded DNA strings that guides the fate of the cells in which they are located.
Questions 68-73 are based on the above passage.
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